Fund a Scientist

Professor Sidney Strickland, PhD, The Rockefeller University

Alzheimer's is a neurodegenerative disease characterized by brain deposits called "amyloid plaques." Amyloid can also damage and block brain blood vessels, starving brain cells of needed oxygen and nutrients and causing their death. In fact, blood vessel damage caused by amyloid may be the link between Alzheimer's disease and vascular risk factors like hypertension, cholesterol, and diabetes. Professor Sidney Strickland is developing drugs to prevent brain blood vessel damage caused by amyloid. Your support will provide crucial funding to further develop these drug candidates by testing them in animal models of Alzheimer's disease.

Fund a Biotech

Signum Biosciences, Gregory Stock, PhD, CEO

Brain cells communicate through cables built with biological tubes called microtubules. As brain cells get damaged in Alzheimer's disease, these microtubules break down and form "neurofibrillary tangles." Tangles contribute to brain cell death and ultimately cognitive loss and dementia. Signum is developing SIG1012, a novel drug candidate originally isolated as a minor component from coffee, to stabilize the microtubules and prevent neurofibrillary tangles. SIG1012 is currently being studied in animal models of Alzheimer's disease. Your funding is needed to advance SIG1012 toward human clinical trials.